General Information

  • ID:  hor001827
  • Uniprot ID:  P58805
  • Protein name:  Conorfamide-Sr1
  • Gene name:  NA
  • Organism:  Conus spurius (Alphabet cone)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Expressed by the venom duct.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lindaconus (subgenus), Conus (genus), Conidae (family), Conoidea (superfamily), Neogastropoda (order), Caenogastropoda (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0090729 toxin activity
  • GO BP:  GO:0035821 modulation of process of another organism
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GPMGWVPVFYRF
  • Length:  12(1-12)
  • Propeptide:  GPMGWVPVFYRF
  • Signal peptide:  NA
  • Modification:  T12 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Cause hyperactivity in mice
  • Mechanism:  The mature peptide does not contain cysteine residue.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001827_AF2.pdbhor001827_ESM.pdb

Physical Information

Mass: 165211 Formula: C73H98N16O14S
Absent amino acids: ACDEHIKLNQST Common amino acids: FGPV
pI: 9.35 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: 43.33 Boman Index: 554
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 48.33
Instability Index: 5126.67 Extinction Coefficient cystines: 6990
Absorbance 280nm: 635.45

Literature

  • PubMed ID:  11738233
  • Title:  Conorfamide, a Conus venom peptide belonging to the RFamide family of neuropeptides.